101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Condensed Consolidated Balance Sheets (Unaudited) link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited) link:calculationLink link:presentationLink link:definitionLink 107 - Disclosure - Nature of the Business and Basis of Presentation link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - Summary of Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Fair Value Measurements and Marketable Securities link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Accrued Expenses link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Notes Payable link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Stock-Based Awards link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Commitments and Contingencies link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Retirement Plan link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Australia Research and Development Tax Incentive link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Restructuring link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Summary of Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Summary of Significant Accounting Policies (Tables) link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Fair Value Measurements and Marketable Securities (Tables) link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Accrued Expenses (Tables) link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Notes Payable (Tables) link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Stock-Based Awards (Tables) link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Commitments and Contingencies (Tables) link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Restructuring (Tables) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Nature of the Business and Basis of Presentation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Summary of Significant Accounting Policies - Summary of Common Stock Equivalents Outstanding (Detail) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Fair Value Measurements and Marketable Securities - Summary of Cash Equivalents and Marketable Securities (Detail) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Fair Value Measurements and Marketable Securities - Summary of Marketable Securities (Detail) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Accrued Expenses - Schedule of Accrued Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Notes Payable - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Notes Payable - Schedule of Notes Payable (Detail) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Stock-Based Awards - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Stock-Based Awards - Summary of Stock-Based Compensation Expense Related to Stock Options and Restricted Common Stock (Detail) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 135 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Lease Payments for Operating Leases (Detail) link:calculationLink link:presentationLink link:definitionLink 136 - Disclosure - Retirement Plan - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 137 - Disclosure - Australia Research and Development Tax Incentive - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 138 - Disclosure - Restructuring - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 139 - Disclosure - Restructuring - Summary of Restructuring Reserve (Detail) link:calculationLink link:presentationLink link:definitionLink