United States securities and exchange commission logo April 30, 2020 Patty Allen Chief Financial Officer Zafgen, Inc. 3 Center Plaza, Suite 610 Boston, Massachusetts 02108 Re: Zafgen, Inc. Preliminary Proxy Statement on Schedule 14A Filed March 6, 2020 File No. 001-36510 Dear Ms. Allen: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Andrew Goodman, Esq.